Apparatus for measuring fluid speed

ABSTRACT

An apparatus for measuring fluid speed by using the refraction of light is disclosed. The apparatus includes: a channel in which a passage is formed to allow the flow of a fluid; a first and a second light source that are located in any one region of an upper part and a lower part of the channel; a sensor installed in an opposite region of the region where the first and second light sources are located with respect to the channel, to receive the light emitted from the first and second light sources; a speed calculation unit configured to calculate a speed of the fluid by using the intensity of the light received at the sensor.

CROSS REFERENCE TO RELATED APPLICATION

This present application is a national stage filing under 35 U.S.C § 371of PCT application number PCT/KR2015/006451 filed on Jun. 24, 2015 whichis based upon and claims the benefit of priority to Korean PatentApplication Nos. 10-2014-0185973 filed on Dec. 22, 2014 in the KoreanIntellectual Property Office. The disclosures of the above-listedapplications are hereby incorporated by reference herein in theirentirety.

BACKGROUND 1. Technical Field

The present invention relates to an apparatus for measuring fluid speed,more particularly to an apparatus for measuring the speed of a fluid byusing the refraction of light emitted from two light sources.

2. Description of the Related Art

As the life expectancy of an average person has increased in moderntimes, so too has the variety of diseases suffered by the average personincreased. As such, various diagnostic devices and diagnostic systemsfor preventing and diagnosing diseases are being developed.

One group of such devices are in vitro diagnostic devices, which usesamples of bodily fluid such as blood, urine, etc., to detect thosesubstances that need to be analyzed. Through quantitative analysis,these devices can quickly determine whether or not a patient has adisease, providing the advantages of speed, efficiency, and accuracy.

Also of interest is the biosensor, hick can be utilized in a variety ofapplications from testing for pregnancy to testing various diseases suchas cancer and multiple sclerosis. As the biosensor uses DNA, minisculeproteins such as antibodies, and the like, the accuracy of the biosensorhas become an important issue. Relevant prior art can be found in KoreanPatent Publication No. 2009-0108428.

In regard to the in vitro diagnostics market, the fluid speed in amicrofluidic channel can be different for each patient, due todifferences in the viscosity of plasma. The measurement of fluid speedis also important in the fields of flow cytometry, cell sorting, microflow switches, etc. However, apparatuses for measuring the speed offluids either are complex, large, and expensive or produce results oflow accuracy.

Thus, there is a need for more research on technology that can providean inexpensive means for accurately measuring the speed of microfluids.

SUMMARY OF THE INVENTION

An objective of the present invention is to provide an apparatus formeasuring fluid speed which not only can provide highly accuratemeasurements but also can be produced with low unit costs.

Another objective of the present invention is to provide an apparatusfor measuring fluid speed that can be easily installed and used and canalso provide highly accurate measurements.

Another objective of the present invention is to provide an apparatusfor measuring fluid speed that uses the refraction of light emitted fromtwo light sources to provide accurate measurements and can adjust thespeed of the fluid based on the measurement results.

To achieve the objectives above, an embodiment of the invention providesan apparatus for measuring fluid speed that includes: a channel, inwhich a passage is formed to allow the flow of a fluid; a first lightsource and a second light source that are located in any one region ofan upper part and a lower part of the channel; a sensor that isinstalled in an opposite region of the region where the first lightsource and the second light source are located with respect to thechannel, to receive the emitted from the first light source and thesecond light source; and a speed calculation unit that calculates thespeed of the fluid by using the intensity of the light received at thesensor.

The apparatus for measuring fluid speed according to an embodiment ofthe invention can be implemented using two light sources and a sensorthat are relatively inexpensive and can be easily installed and readilyused by any user.

Thus, an embodiment of the invention provides an apparatus for measuringfluid speed which not only can provide highly accurate measurements butalso can be produced with low unit costs.

Additional aspects and advantages of the present invention will be setforth in part in the description which follows, and in part will beobvious from the description, or may be learned by practice of theinvention.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 and FIG. 2 illustrate an apparatus for measuring fluid speedassociated with an embodiment of the invention.

FIG. 3 shows a graph representing the principle used in measuring thespeed of a fluid with an apparatus for measuring fluid speed associatedwith an embodiment of the invention.

FIG. 4 illustrates an apparatus for measuring fluid speed associatedwith another embodiment of the invention.

FIG. 5, FIG. 6, and FIG. 7 show graphs representing principles used inmeasuring the speed of a fluid and controlling the flow speed with anapparatus for measuring fluid speed associated with an embodiment of theinvention.

DETAILED DESCRIPTION OF THE INVENTION

An apparatus for measuring fluid speed associated with an embodiment ofthe invention is described below with reference to the appendeddrawings.

In the present specification, an expression used in the singularencompasses the expression of the plural unless it has a clearlydifferent meaning in the context. In the present specification, termssuch as “comprising” or “including,” etc., should not be interpreted asmeaning that all of the elements or operations listed in thespecification are necessarily included. That is, some of the elements oroperations may not be included, while other additional elements oroperations may be further included.

The ‘speed of a fluid’, as referred to in the present specification, canrepresent the speed at which a fluid fills a channel. Also, ‘flow speedcontrol’ in the present specification can represent the control of theflow speed of a fluid during the process of the fluid filling thechannel.

FIG. 1 and FIG. 2 illustrate an apparatus for measuring fluid speedassociated with an embodiment of the invention.

As illustrated in the drawings, an apparatus 100 for measuring fluidspeed can include a channel 110, a first light source 121, a secondlight source 122, a sensor and a speed calculation unit 140.

Within the channel 110, a passage is provided through which a fluid canflow. The fluid can include a microfluid and can serve as a testspecimen. A test specimen refers to a solution subjected to testing andis a substance that is suspected of containing a target of analysis. Forexample, the test specimen can be a physiological fluid obtained from abiological source (e.g. a person, an animal, etc.), such as blood,saliva, cerebrospinal fluid, sweat, urine, milk, ascitic fluid, mucus,nasal fluid, hemoptoe, synovial fluid, abdominal fluid, and others.

Also, the test specimen can be obtained directly from a biologicalsource or can be pretreated to reform the properties of the testspecimen. Methods of pretreatment can include filtration, sedimentation,dilution, concentration, deactivation of interference components, lysis,adding reagents, and the like. For instance, a procedure of separatingthe plasma from a blood sample, or the like, can be performed.

The first light source 121 and second light source 122 can be positionedin a region above the channel 110 (i.e. in a region of an upper part ofthe channel 110), while the sensor 130 can be installed in a regionbelow the channel (i.e. in a region of a lower part of the channel 110).

Of course, although it is not illustrated in the drawings, it is alsopossible to position the first light source 121 and second light source122 below the channel 110 and install the sensor 130 above the channel.That is, according to an embodiment of the invention, the sensor 130 maybe installed in an opposite region of the region where the first lightsource 121 and the second light source 122 are located, with respect tothe channel 110.

The first light source 121 and the second light source 122 can bepositioned such that light emitted from the light sources has incidentangles other than 90 degrees with respect to the channel 110. If thelight emitted from the first light source 121 and second light source122 has an incident angle of 90 degrees with respect to the channel 110,then the light may be dispersed due to reflection, scattering, etc.,resulting in a lowered sensitivity of the measurement.

Also, the first light source 121 and the second light source 122 can bepositioned such that the light sources are not parallel with each other.If the angle between the first light source 121 and second light source122 were to form 180 degrees (i.e. if the light sources were parallel),then the size of the sensor 130 for receiving the light emitted from thefirst light source 121 and second light source 122 would have to belarger and would thus incur higher costs.

Also, the angles and directions of the first light source 121 and secondlight source 122 with respect to the channel 110 may be adjustable. FIG.2 shows an example in which the angles of the first light source 121 andsecond light source 122 with respect to the channel 110 have beenadjusted from the arrangement shown in FIG. 1.

The angles and directions of the first light source 121 and second lightsource 122 can be adjusted, for example, according to the type of laseremitted by light source 121 and second light source 122. Also, theangles and directions of the first light source 121 and second lightsource 122 may be adjusted according to the structure of the chipsupport (not shown) or the shape of the chip.

The sensor 130 may be installed in a region below the channel 110 toreceive the light emitted from the first light source 121 and secondlight source 122. The sensor 130 can be installed to receive all of thelight emitted from both of the light sources 121, 122. That is, anapparatus for measuring fluid speed according to an embodiment of theinvention enables lowered cost by utilizing a structure in which onesensor is used to receive light from two light sources.

Also, according to an embodiment of the invention, the first lightsource 121, the second light source 122, and the sensor 130 can bepositioned such that the light emitted from the first light source 121and the light emitted from second light source 122 intersect in a regionbelow the channel 110 before being received at the sensor 130. By thushaving the light intersect in a region at a lower part of the channel110 and then enter the sensor 130, it is possible to reduce the size ofthe sensor 130.

The larger the distance (k) between the sensor 130 and the channel 110,the weaker the intensity of the light received at the sensor 130, andhence the lower the accuracy of the measurement. Thus, in considerationof the type of microfluid and the distance from the light sources, etc.,the distance k can be set as 0.1-10 mm.

Also, the size of the sensor 130 can vary depending on the distance (d)between the first incident point, where the light emitted from the firstlight source 121 meets the channel 110, and the second incident point,where the light emitted from the second light source 122 meets thechannel 110. Thus, in consideration of the fact that the type of fluidbeing measured is a microfluid, the distance d can be set as 1-10 mm.

The speed measurement unit 140 can measure the speed of the fluid byusing the intensity of the light received at the sensor 130.

FIG. 3 shows a graph representing the principle used in measuring thespeed of a fluid with an apparatus for measuring fluid speed associatedwith an embodiment of the invention.

The graph can be divided into three regions by the vertical dottedlines. The left region represents the initial state where there is nofluid flowing in the channel 110, so that the two types of light emittedfrom the first light source 121 and the second light source 122 arereceived at the sensor 130 without any refraction. The middle regionrepresents the state where the fluid has flowed only up to a certainspace within the channel 110, so that the light emitted from the firstlight source 121 is received at the sensor 130 after it is refracted,but the light emitted from the second light source 122 is received atthe sensor 130 without refraction. The right region represents the statewhere the fluid has sufficiently flowed within the channel 110, so thatthe light from the first light source 121 and the light from the secondlight source 122 are all refracted before being received at the sensor130.

As can be seen from the graph of FIG. 3, the intensity of the light mayundergo changes at a first refraction time point (the time point atwhich the light from the first light source begins) and at a secondrefraction time point (the time point at which the light from the secondlight source begins).

The time (t) it takes for the fluid to flow across distance d duringthis time difference between the refraction time points can be measured.

The speed calculation unit 140 can calculate the speed of the fluid byusing the time t and the distance d.

According to an embodiment of the invention, the apparatus for measuringfluid speed can adjust the flow speed of the fluid based on the measuredspeed of the fluid.

FIG. 4 illustrates an apparatus for measuring fluid speed associatedwith another embodiment of the invention.

As illustrated in the figure, an apparatus 200 for measuring fluid speedcan include a channel 210, a first light source 221, a second lightsource 222, a sensor 230, a speed calculation unit 240, and anadjustment unit 250.

Within the channel 210, a passage is provided through which a fluid canflow. The fluid can include a microfluid and can serve as a testspecimen.

The first light source 221 and second light source 222 can be positionedin a region above the channel 210, while the sensor 230 can be installedin a region below the channel.

Of course, although it is shown in the drawings, it is also possible toposition the first light source 221 and second light source 222 belowthe channel 210 and install the sensor 230 above the channel. That is,according to an embodiment of the invention, the sensor 230 may beinstalled in an opposite region of the region where the first lightsource 221 and the second light source 222 are located, with respect tothe channel 210.

The first light source 221 and the second light source 222 can bepositioned such that light emitted from the light sources has incidentangles other than 90 degrees with respect to the channel 210. If thelight emitted from the first light source 221 and second light source222 has an incident angle of 90 degrees with respect to the channel 210,then the light may be dispersed due to reflection, scattering, etc.,resulting in a lowered sensitivity of the measurement.

Also, the first light source 221 and the second light source 222 can bepositioned such that the light sources are not parallel with each other.If the angle between the first light source 221 and second light source222 were to form 180 degrees (i.e. if the light sources were parallel),then the size of the sensor 230 for receiving the light emitted from thefirst light source 221 and second light source 222 would have to belarger and would thus incur higher costs.

Also, the angles and directions of the first light source 221 and secondlight source 222 with respect to the channel 210 may be adjustable.

The angles and directions of the first light source 221 and second lightsource 222 can be adjusted, for example, according to the type of laseremitted by the first light source 221 and second light source 222. Also,the angles and directions of the first light source 221 and second lightsource 222 may be adjusted according to the structure of the chipsupport (not shown) or the shape of the chip.

The sensor 230 may be installed in a region below the channel 210 toreceive the light emitted from the first light source 221 and secondlight source 222. The sensor 230 can be installed to receive all of thelight emitted from both of the light sources 221, 222. That is, anapparatus for measuring fluid speed according to an embodiment of theinvention enables lowered cost by utilizing a structure in which onesensor is used to receive light from two light sources.

Also, according to an embodiment of the invention, the first lightsource 221, the second light source 222, and the sensor 230 can bepositioned such that the light emitted from the first light source 221and the light emitted from the second light source 222 intersect in aregion below the channel 210 before being received at the sensor 230. Bythus having the light intersect in a region at a lower part of thechannel 210 and then enter the sensor 230, it is possible to reduce thesize of the sensor 230.

The speed measurement unit 240 can measure the speed of the fluid byusing the intensity of the light received at the sensor 230. Regardingthe measuring of the speed of the fluid, the descriptions provided withreference to FIG. 3 also apply here.

The adjustment unit 250 can adjust the flow speed of the flowing fluidbased on the calculated speed of the fluid. The adjustment unit 250 caninclude a vent hole part 251, a tube 252, a valve 253, and a controllerpart 254.

The vent hole part 251 can be connected with the exterior of the channel210 to exhaust air inside the channel 210 to the outside.

The valve 253 can be connected to the entrance part of the vent holepart 251 by way of a tube 252 and can open and close the entrance partof the vent hole part 251 according to a preset time schedule.

The controller part 254 can control the operation of the valve 253. Forexample, the controller part 254 can apply On signals and Off signals tothe valve 253 based on the calculated speed of the fluid. Morespecifically, the controller part 254 can determine the durations forapplying an On signal and an Off signal, the number of times the signalsare applied, the order in which they are applied, and the like. Inparticular, the durations of the On signal and Off signal, the number ofsignal applications, and the order of the signal applications can bestored in the form of a table in the controller part 254.

When the On signal and Off signal for the valve 253 are determined asabove according to the flow speed of the fluid, the controller part 254can control the valve 253. More specifically, the controller part 254can alternatingly apply On signals and Off signals to the valve 253.

Also, the controller part 54 can set the duration of an On signal andthe duration of an Off signal to be different from each other. Morespecifically, the duration of applying an On signal can be formedshorter than the duration of applying an Off signal.

For example, the controller part 254 can apply the On signal to thevalve 253 for a first duration if the flow speed of the fluid is a firstflow speed. Also, the controller part 254 can apply the Off signal tothe valve 253 for a second duration. Here, the first duration and thesecond duration can be formed differently as described above.

FIG. 5 shows a graph representing the principles used in controllingflow speed with an apparatus for measuring fluid speed associated withan embodiment of the invention.

tp represents the sum of the durations of an opening and a closing ofthe valve and thus represents the duration of a unit periodic cycle.tp=valve open duration (to)+valve closed duration (tc). v represents themeasured flow speed.

When the vent hole part 251 connected with the channel 210 is closed, anamount of air pressure may be applied on the substance flowing insidethe channel 210 because of the air within the channel 210, and if theresistance due to air pressure becomes the same as the capillary forceof the channel, the substance within the channel may become immobile.Furthermore, since the viscosity of a fluid may change with time, theflow speed can be adjusted in consideration of the changing viscosity ofthe fluid.

FIG. 6 represents the relationship between flow speed and time when tpis constant, and FIG. 7 represents the relationship the measured flowspeed and the moving distance of the fluid.

If the flow speed is high, then the distance moved during the openduration would be large, and as such, it may be conceivable to decreasethe open duration and increase the closed duration. Also, since a higherflow speed results in an increased moving distance per unit time, it maybe conceivable to keep the flow speed constant by regulating the openduration.

The measuring of the speed of a fluid according to an embodiment of theinventions described above can be adopted even for transparent fluids,since it uses the refraction of light.

The method of measuring and controlling fluid speed described above canbe implemented in the form of program instructions that may be performedusing various computer means and can be recorded in a computer-readablemedium. Such a computer-readable medium can include programinstructions, data files, data structures, etc., alone or incombination. The program instructions recorded on the medium can bedesigned and configured specifically for the invention or can be a typeof medium known to and used by the skilled person in the field ofcomputer software.

A computer-readable medium may include a hardware device that isspecially configured to store and execute program instructions. Someexamples may include magnetic media such as hard disks, floppy disks,magnetic tapes, etc., optical media such as CD-ROM's, DVD's, etc.,magneto-optical media such as floptical disks, etc., and hardwaredevices such as RUM, RAM, flash memory, etc.

On the other hand, the computer-readable medium can be a transmissionmedium, such as optical signals, metal-based lines, waveguides, etc.,which transmit carrier waves that transmit signals for specifyingprogram commands, data structures, and the like.

Examples of the program of instructions may include not only machinelanguage codes produced by a compiler but also high-level language codesthat can be executed by a computer through the use of an interpreter,etc. The hardware mentioned above can be made to operate as one or moresoftware modules that perform the actions of the embodiments of theinvention, and vice versa.

An apparatus for measuring fluid speed as described above is not to belimited to the compositions and methods associated with the embodimentsdisclosed above. The above embodiments allow for various modifications,and it is conceivable to selectively combine all or some of the featuresof the various embodiments.

What is claimed is:
 1. An apparatus for measuring fluid speed, theapparatus comprising: a channel having a passage formed therein forholding a fluid flowing therethrough; a first light source and a secondlight source located in any one region of an upper part and a lower partof the channel; a sensor installed in an opposite region of the regionwhere the first light source and the second light source are locatedwith respect to the channel, the sensor configured to receive lightemitted from the first light source and the second light source; and aspeed calculation unit configured to calculate a speed of the fluid byusing an intensity of light received at the sensor, wherein the speedcalculation unit calculates the speed of the fluid by using a time pointat which the intensity of the light changes and distance informationregarding a distance between a first incident point and a secondincident point, the first incident point being a point where the lightemitted from the first light source meets the channel, and the secondincident point being a point where the light emitted from the secondlight source meets the channel, wherein an angle of the first lightsource and the second light source with respect to the channel isadjustable.
 2. The apparatus for measuring fluid speed of claim 1,wherein a size of the sensor is determined based on a distance betweenthe channel and the sensor.
 3. The apparatus for measuring fluid speedof claim 1, wherein the first light source and the second light sourceare positioned such that light is not incident a perpendicular anglewith respect to a direction of a flow of the fluid formed in thechannel.
 4. The apparatus for measuring fluid speed of claim 1, whereinthe first light source and the second light source are positioned suchthat light emitted from the first light source and light emitted fromthe second light source are not parallel with each other.
 5. Theapparatus for measuring fluid speed of claim 4, wherein light emittedfrom the first light source and light emitted from the second lightsource are received at the sensor after intersecting in the oppositeregion.